Golden Globes 2016 host Ricky Gervais aims at Sean Penn and Caitlyn Jenner

It’s his fourth time on the Golden Globes podium, and it seems host Ricky Gervais is determined to make it his last.

Nobody was safe as the 54-year-old funnyman let rip at the A-listers on Sunday night.

One outrageous gag saw Ricky introducing presenter Matt Damon while poking fun at the Hollywood Foreign Press considering his space drama a comedy and even took a dig at the 45-year-old actor’s best friend.

The funnyman quipped: ‘It’s the star of the hilarious comedy The Martian. He is also the only person that Ben Affleck hasn’t been unfaithful to.’

Matt, obviously caught off-guard by the comment, certainly seemed to have a sense of humour about the joke as he couldn’t help but smile and hold back laughter as he introduced his film.

Scroll down for video 

From joking about Caitlyn Jenner’s driving to ‘snitch’ Sean Penn, and even a gasp-inducing anecdote about shoving one of his Globes ‘up my a**’, the British comedian did his best to entertain - and insult.  

He did not pull any punches as poked fun at women’s pay scale disparities, Caitlyn Jenner, The Martian being considered a comedy and even hinted at the vile things he has done with the awards he has won during the gala event held at the Beverly Hilton in Beverly Hills California on Sunday evening.

As he insisted that he was going to be nicer in comparison to past years, one of his first jokes was aimed at the 65-year-old Keeping Up With The Kardashians star as he joked:  ‘I’ve changed. Not as much as Bruce Jenner, now known as Caitlyn Jenner. 

‘What a year she’s had. She’s become a role model for trans people everywhere, showing great bravery and destroying stereotypes. She didn’t do a lot for women drivers. You can’t have everything, can you, not at the same time.’

Just ahead of the event, The Office star couldn’t help but push the envelope once again as he sent out a rather crude tweet ahead of his hosting gig. 

‘Better get dressed and offend some humourless c**ts I suppose,’ he wrote alongside a shot of him looking incredibly disheveled.

He later posted a selfie that showed him looking sharp in shades and a black houndstooth patterned suit. 

By the time Gervais arrived on the red carpet he was on fine form, jokingly pretending to be drunk.

‘I’m heavily sedated under doctor’s orders,’ he told a skeptical Ryan Seacrest.

When Ryan asked Jane Fallon, Gervais’ partner of some 33 years, if the star had actually been drinking, she replied: ‘Before, during, after.’

Gervais agreed, adding: ‘Just a little.’

He then bluntly told Ryan: ‘I’m looking forward to it being over. I’m not cut out for this.’

The British comedian is taking back hosting duties from the popular duo Tina Fey and Amy Poehler. He has hosted it three-times previously in 2010, 2011 and 2012.

Gervais already prepared viewers for his sometimes cruel jokes as he tweeted a cheeky apology days earlier for those who will be offended by his jokes. 

He wrote on Twitter New Year’s Day: ‘Because I can see the future, I’d like to apologise now for the things I said at next week’s Golden Globes. I was drunk & didn’t give a f***.’

Gervais has been given free reign on stage, despite the controversy surrounding his past quips about Scientology, Mel Gibson and how making a Holocaust movie guarantees awards glory.

‘They said I could say what I want again,’ the he Ellen DeGeneres during a recent interview.

Gervias is the star and brains behind the popular TV shows The Office, Extras, and Derek has won seven Bafta awards, five British comedy awards, three Golden Globes and two Emmys.

The Golden Globes is regarded as the second most prestigious awards ceremony for American film, just behind the Academy Awards.

The awards are bestowed by the 93 members of the Hollywood Foreign Press Association (HFPA) and recognises excellence in film and television, both domestic and foreign.

Going into Sunday night, Todd Haynes’ 1950s romance Carol leads all nominees with five nods, including best picture (drama) and best actress for both of its leads, Cate Blanchett and Rooney Mara. 

In the best picture category, it will compete with Spotlight, The Revenant, Room and Mad Max: Fury Road.

Netflix earned a leading eight nods on the TV side, where nominations were scattered across streaming services, broadcast and cable. 

Six shows come in tied for the most nominations with three: Fargo, Mr. Robot, Outlander, Transparent, American Crime and Wolf Hall.

See live updates from the 2016 Golden Globes with all the latest red carpet pictures and videos